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Combined endocrine and chemotherapy in breast cancer 

Combined endocrine and chemotherapy in breast cancer
Combined endocrine and chemotherapy in breast cancer

Ishmael Jaiyesimi

, Shannon Wills

, Richard Zekman

, Dave Decker

, and Aman U. Buzdar

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date: 02 June 2020

Combining adjuvant endocrine therapy with tamoxifen, and chemotherapy is superior than either modality alone.

Sequentially administered antiestrogen therapy is better than concomitant administration with chemotherapy.

Efficacy of aromatase inhibitors is not altered by prior adjuvant chemotherapy.

The role of ovarian ablation or suppression in premenopausal women following adjuvant chemotherapy remains an area of ongoing research.

In metastatic disease, endocrine therapies and chemotherapies should be sequentially utilized - concomitant use offers no advantage.

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