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Progestins and androgens 

Progestins and androgens
Chapter:
Progestins and androgens
Author(s):

Janet L. Espirito

DOI:
10.1093/med/9780199218141.003.0006
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date: 05 June 2020

Progestins and androgens are synthetic derivatives of the natural hormones progesterone and testosterone, used in the treatment of metastatic breast cancer.

Although the mechanisms for how they work are unknown, these are effective therapies for patients with hormone responsive disease.

The most widely used progestins are medroxypro-gesterone acetate and megestrol acetate. Fluoxy-mesterone is the androgen most commonly used.

Based on tolerability and efficacy, progestins and androgens have moved sequentially down the line of treatment following progression on aromatase inhibitors and antioestrogens.

Although these are older compounds, they are generally well tolerated and still have a role in therapy.

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