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John F. Forbes

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date: 05 June 2020

Oestrogen acts via nuclear oestrogen receptors and (ER) formation of the ER oestrogen complex triggers transcription.

Antioestrogen treatments include selective oestrogen receptor modulators (SERMs), and strategies to reduce oestrogen levels by suppression of ovary function in premenopausal women and by blocking the aromatase enzyme in postmenopausal women.

Tamoxifen is the most important SERM. It is effective, generally well tolerated, and inexpensive. It is active against both early and advanced breast cancer and is an effective preventative agent for women at increased risk.

Other SERMs include raloxifene which is an effective prevention agent.

Antioestrogen therapies will remain important for breast cancer treatment and prevention. Drugs with a better side effect profile are needed.

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