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Ovarian ablation 

Ovarian ablation
Chapter:
Ovarian ablation
Author(s):

Kellie L. Jones

DOI:
10.1093/med/9780199218141.003.0002
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date: 29 May 2020

Ovarian ablation can be achieved through oophorectomy, irradiation, or via medical ablation (chemo-therapy-induced or with the administration of luteinizing hormone releasing hormone (LHRH) agonists).

An oophorectomy is effective in reducing levels of oestrogen to a menopausal state, but this procedure is irreversible.

Radiation therapy to the ovaries can induce post-menopausal oestrogen levels; however this technique is slow to take effect and is not 100% effective.

LHRH agonist therapy can induce reversible ovarian suppression and is well tolerated.

Studies have reported that ovarian ablation/suppression reduces the recurrence and mortality rates in the treatment of early breast cancer.

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