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Metabolic disorders 

Metabolic disorders
Metabolic disorders

Sheila K. Adam

and Sue Osborne

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date: 26 June 2022

Phaeochromocytoma 488

Addison’s disease 490

Hypothyroidism: myxoedema 492

Hyperthyroidism: thyrotoxicosis 494

Hypocalcaemia 496

Hypercalcaemia 498

Diabetic ketoacidosis 500

Hyperosmolar, hyperglycaemic states 502

Hypoglycaemia 503

Diabetes insipidus (DI) 504

A tumour of chromaffin cells, where high levels of adrenaline (epinephrine) and noradrenaline (norepinephrine) are secreted. It usually originates in the adrenal medulla, but can occur anywhere along the sympathetic chain (aorta, bladder, pelvis, abdomen, thorax). The secretion of catecholamines is usually intermittent causing acute attacks of severe hypertension; between attacks the blood pressure may be only slightly raised. Depending on the type of catecholamine secreted, it may present as episodes of hypotension, which can be mistaken for septic shock....

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