Show Summary Details
Page of

Bisphosphonates for bone pain 

Bisphosphonates for bone pain
Chapter:
Bisphosphonates for bone pain
Author(s):

Rebecca Wong

DOI:
10.1093/med/9780199215737.003.0007
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2020. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 29 March 2020

In the 1960s, Fleisch and Bisaz identified substances in the blood and urine that prevented the formation and dissolution of calcium phosphate crystals, which were later characterized as pyrophosphates (Fleisch and Bisaz, 1962). Recognizing their biophysical properties, Fleisch hypothesized that pyrophosphates were an important regulator of bone mineralization and demineralization, and potentially useful in preventing or treating abnormal calcification and excessive bone destruction (Fleisch, 1987). This chapter will discuss the data on bisphosphonates in the management of cancer-related bone pain.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.