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Bisphosphonates for bone pain 

Bisphosphonates for bone pain
Bisphosphonates for bone pain

Rebecca Wong

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date: 27 October 2020

In the 1960s, Fleisch and Bisaz identified substances in the blood and urine that prevented the formation and dissolution of calcium phosphate crystals, which were later characterized as pyrophosphates (Fleisch and Bisaz, 1962). Recognizing their biophysical properties, Fleisch hypothesized that pyrophosphates were an important regulator of bone mineralization and demineralization, and potentially useful in preventing or treating abnormal calcification and excessive bone destruction (Fleisch, 1987). This chapter will discuss the data on bisphosphonates in the management of cancer-related bone pain.

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