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Dermatological emergencies 

Dermatological emergencies
Chapter:
Dermatological emergencies
DOI:
10.1093/med/9780199215638.003.0011
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date: 13 October 2019

Paraneoplastic pemphigus 322

The pemphigus family of skin disorders is a collection of autoimmune blistering conditions affecting the skin and/or mucous membranes. Paraneoplastic pemphigus occurs in patients with a known or occult neoplasm. It is a very rare phenomenon associated with autoantibodies to various antigens contained in desmosomes and hemi-desmosomes. The antibodies attack the desmosomes of keratinocytes via a type II hypersensitivity reaction, causing them to separate. The gaps between the cells then fill with fluid, causing the skin to blister or peel off, leaving raw areas. Treatment of an underlying malignancy does not appear to affect the outcome, but treatment of benign conditions (e.g. thymoma) can lead to resolution....

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