Show Summary Details
Page of

Dermatological emergencies 

Dermatological emergencies
Dermatological emergencies
Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2016. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 13 October 2019

Paraneoplastic pemphigus 322

The pemphigus family of skin disorders is a collection of autoimmune blistering conditions affecting the skin and/or mucous membranes. Paraneoplastic pemphigus occurs in patients with a known or occult neoplasm. It is a very rare phenomenon associated with autoantibodies to various antigens contained in desmosomes and hemi-desmosomes. The antibodies attack the desmosomes of keratinocytes via a type II hypersensitivity reaction, causing them to separate. The gaps between the cells then fill with fluid, causing the skin to blister or peel off, leaving raw areas. Treatment of an underlying malignancy does not appear to affect the outcome, but treatment of benign conditions (e.g. thymoma) can lead to resolution....

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.