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Adjuvant therapy 

Adjuvant therapy
Chapter:
Adjuvant therapy
Author(s):

James Harvey

, Sue Down

, Rachel Bright-Thomas

, John Winstanley

, and Hugh Bishop

DOI:
10.1093/med/9780199215065.003.0013
Page of

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date: 19 September 2021

Adjuvant therapy. Advancements in adjuvant therapy for breast cancer have contributed significantly to the reduction in breast cancer mortality. Various adjuvant therapies are available to the oncologist, both in the neo-adjuvant (pre-surgery) and adjuvant (post-surgery) setting. These treatments complement surgery in reducing local disease recurrence, but also treat systemic disease effectively. The indications for radiotherapy are discussed, including the most recent trials which are currently in progress. Methods of action of the available hormonal therapies are described, along with their specific indications, and the evidence for their use. Chemotherapy is covered in some detail in this chapter, and the decision-making pathway for individual cases is explained. Finally, the benefits of new biological modifiers such as Herceptin and Lapatinib are discussed.

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