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Ischaemic heart disease, arrhythmias, and heart failure 

Ischaemic heart disease, arrhythmias, and heart failure
Chapter:
Ischaemic heart disease, arrhythmias, and heart failure
Author(s):

M Patrick

DOI:
10.1093/med/9780199209101.003.04
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date: 04 July 2020

Ischaemic heart disease (IHD) 52

Perioperative arrhythmias 60

Heart failure (HF) 64

Further reading 70

( see also Chapter 11)

The arterial wall contains three layers, the intima, media, and adventitia. The intima is lined by endothelium. The endothelium is unique in that blood does not coagulate on it despite prolonged contact. This is largely due to the expression of heparan sulphate on the surface of endothelial cells, which interacts with antithrombin III, inhibiting thrombin. Healthy endothelial cells also express fibrinolytic activity. IHD is caused by formation of atheromatous plaques in the coronary arteries, which cause progressive narrowing of the arterial lumen (atherogenesis)....

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