- 1 On being a patient
- 2 Modern medicine: foundations, achievements, and limitations
- 3 Global patterns of disease and medical practice
- 4 Cell biology
- 4.1 The cell
- 4.2 Molecular biology
- 4.2.1 The human genome sequence
- 4.2.2 The genomic basis of medicine
- 4.3 Cytokines
- 4.4 Ion channels and disease
- 4.5 Intracellular signalling
- 4.6 Apoptosis in health and disease
- 4.7 Discovery of embryonic stem cells and the concept of regenerative medicine
- 4.8 Stem cells and regenerative medicine
- 5 Immunological mechanisms
- 6 Principles of clinical oncology
- 7 Infection
- 8 Sexually transmitted diseases and sexual health
- 9 Chemical and physical injuries and environmental factors and disease
- 10 Clinical pharmacology
- 11 Nutrition
- 12 Metabolic disorders
- 13 Endocrine disorders
- 14 Medical disorders in pregnancy
- 15 Gastroenterological disorders
- 16 Cardiovascular disorders
- 17 Critical care medicine
- 18 Respiratory disorders
- 19 Rheumatological disorders
- 20 Disorders of the skeleton
- 21 Disorders of the kidney and urinary tract
- 22 Disorders of the blood
- 23 Disorders of the skin
- 24 Neurological disorders
- 25 The eye
- 26 Psychiatry and drug related problems
- 27 Forensic medicine
- 28 Sports medicine
- 29 Geratology
- 30 Pain
- 31 Palliative medicine
- 32 Biochemistry in medicine
- 33 Acute medicine
The human genome sequence
- Chapter:
- The human genome sequence
- Author(s):
Sydney Brenner
- DOI:
- 10.1093/med/9780199204854.003.40201
The ability to clone and propagate fragments of DNA, along with technical advances that allow the order of nucleotide bases to be determined, has led to sequencing of the entire human genome. It may be that ultimately this information will lead to the uncovering of numerous targets for therapeutic purposes, but much additional biological and clinical research will be required on gene and protein function in living cells, whole organisms and people....
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- 1 On being a patient
- 2 Modern medicine: foundations, achievements, and limitations
- 3 Global patterns of disease and medical practice
- 4 Cell biology
- 4.1 The cell
- 4.2 Molecular biology
- 4.2.1 The human genome sequence
- 4.2.2 The genomic basis of medicine
- 4.3 Cytokines
- 4.4 Ion channels and disease
- 4.5 Intracellular signalling
- 4.6 Apoptosis in health and disease
- 4.7 Discovery of embryonic stem cells and the concept of regenerative medicine
- 4.8 Stem cells and regenerative medicine
- 5 Immunological mechanisms
- 6 Principles of clinical oncology
- 7 Infection
- 8 Sexually transmitted diseases and sexual health
- 9 Chemical and physical injuries and environmental factors and disease
- 10 Clinical pharmacology
- 11 Nutrition
- 12 Metabolic disorders
- 13 Endocrine disorders
- 14 Medical disorders in pregnancy
- 15 Gastroenterological disorders
- 16 Cardiovascular disorders
- 17 Critical care medicine
- 18 Respiratory disorders
- 19 Rheumatological disorders
- 20 Disorders of the skeleton
- 21 Disorders of the kidney and urinary tract
- 22 Disorders of the blood
- 23 Disorders of the skin
- 24 Neurological disorders
- 25 The eye
- 26 Psychiatry and drug related problems
- 27 Forensic medicine
- 28 Sports medicine
- 29 Geratology
- 30 Pain
- 31 Palliative medicine
- 32 Biochemistry in medicine
- 33 Acute medicine