Show Summary Details
Page of

Disorders of the neuromuscular junction 

Disorders of the neuromuscular junction
Disorders of the neuromuscular junction

David Hilton-Jones

and Jacqueline Palace


July 30, 2015: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.


Identification of low-affinity antibodies in acquired myasthenia gravis aids diagnosis.

Possibility of newly identified antibody targets in myasthenia.

Move towards keyhole surgery for thymectomy rather than conventional sternal-splitting surgery.

Advice with respect to drug therapy in pregnancy.

Update on congenital myasthenic syndromes.

Further reading added.

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 19 September 2021

Two fundamentally different pathological processes are associated with disease at the neuromuscular junction: (1) acquired disorders in which autoantibodies are directed against nerve or muscle receptor or ion channels; (2) rare inherited conditions in which the defect may be pre- or postsynaptic.

Aetiology and epidemiology—the fundamental disorder is loss of functional acetylcholine receptors most frequently as a result of binding of anti-acetylcholine receptor (anti-AChR) antibodies. Incidence is about 10 per million population and prevalence about 8 per 100 000, with a marked female bias in cases aged under 40 years and male preponderance in those over 50 years. Thymomas occur in about 10% of cases....

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.