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Autoimmune limbic encephalitis and Morvan’s syndrome 

Autoimmune limbic encephalitis and Morvan’s syndrome
Autoimmune limbic encephalitis and Morvan’s syndrome

Camilla Buckle

and Angela Vincent



Additional information on VGKC-complex antibodies.

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date: 19 September 2021

Autoimmune limbic encephalitis—typical presentation is with acute or subacute onset of short term memory loss, seizures and disorientation. MRI characteristically shows striking abnormalities in the hippocampus. Antibodies against cell-surface proteins that are components of voltage-gated potassium channel (VGKC) complexes are found in a high proportion and are probably pathogenic. Aside from supportive care, treatment is with immunosuppression, often comprising corticosteroids with intravenous immunoglobulin and/or plasma exchange....

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