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Paraneoplastic neurological syndromes 

Paraneoplastic neurological syndromes
Paraneoplastic neurological syndromes

Jeremy Rees

and Angela Vincent



Recent incidence data.

Onconeural antibody associated disorders and NMDAR antibody encephalitis.

Further reading updated.

Other minor changes.

A relevant case history from Neurological Case Histories: Case Histories in Acute Neurology and the Neurology of General Medicine has been added to this chapter.

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date: 27 September 2021

Case History—A 32 yr old man presenting with drowsiness and confusion.

Paraneoplastic neurological syndromes are disorders caused by the presence of an underlying tumour, but not due to either direct or metastatic invasion, or to recognized metabolic or endocrine complications. They are thought to arise from an autoimmune response to onconeural tumour antigens which are also expressed by cells of the central or peripheral nervous system....

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