- 1 On being a patient
- 2 Modern medicine: foundations, achievements, and limitations
- 3 Global patterns of disease and medical practice
- 4 Cell biology
- 5 Immunological mechanisms
- 6 Principles of clinical oncology
- 7 Infection
- 8 Sexually transmitted diseases and sexual health
- 9 Chemical and physical injuries and environmental factors and disease
- 10 Clinical pharmacology
- 11 Nutrition
- 12 Metabolic disorders
- 13 Endocrine disorders
- 14 Medical disorders in pregnancy
- 15 Gastroenterological disorders
- 16 Cardiovascular disorders
- 17 Critical care medicine
- 18 Respiratory disorders
- 19 Rheumatological disorders
- 20 Disorders of the skeleton
- 21 Disorders of the kidney and urinary tract
- 22 Disorders of the blood
- 23 Disorders of the skin
- 24 Neurological disorders
- 24.1 Introduction and approach to the patient with neurological disease
- 24.2 Mind and brain: building bridges linking neurology, psychiatry, and psychology
- 24.3 Clinical investigation of neurological disease
- 24.4 Higher cerebral function
- 24.5 Epilepsy and disorders of consciousness
- 24.6 Disorders of the special senses
- 24.7 Disorders of movement
- 24.8 Headache
- 24.9 Brainstem syndromes
- 24.10 Specific conditions affecting the central nervous system
- 24.11 Infections of the central nervous system
- 24.12 Disorders of cranial nerves
- 24.13 Disorders of the spinal cord
- 24.14 Diseases of the autonomic nervous system
- 24.15 The motor neuron diseases
- 24.16 Diseases of the peripheral nerves
- 24.17 Inherited neurodegenerative diseases
- 24.18 Developmental abnormalities of the central nervous system
- 24.19 Acquired metabolic disorders and the nervous system
- 24.20 Neurological complications of systemic disease
- 24.21 Paraneoplastic neurological syndromes
- 24.22 Autoimmune limbic encephalitis and Morvan’s syndrome
- 24.23 Disorders of the neuromuscular junction
- 24.24 Disorders of muscle
- 25 The eye
- 26 Psychiatry and drug related problems
- 27 Forensic medicine
- 28 Sports medicine
- 29 Geratology
- 30 Pain
- 31 Palliative medicine
- 32 Biochemistry in medicine
- 33 Acute medicine
(p. 5158) Neurological complications of systemic disease
- Chapter:
- (p. 5158) Neurological complications of systemic disease
- Author(s):
Neil Scolding
- DOI:
- 10.1093/med/9780199204854.003.2420
Primary neuroimmune disorders such as multiple sclerosis or the Guillain–Barré syndrome are well recognized (and described elsewhere in this section), but there are numerous diverse systemic inflammatory, infective, or immunological disorders that can affect the nervous system.
Autoimmune rheumatic disorders—(1) Systemic lupus erythematosus—neurological manifestations include headache, acute or subacute encephalopathy, fits, myelitis, strokes and movement disorders (including chorea and other extrapyramidal disorders), ataxia and brainstem abnormalities, cranial and peripheral neuropathies, and psychiatric and cognitive disturbances. Risk of stroke is particularly associated with the lupus anticoagulant and the primary antiphospholipid syndrome. (2) Other conditions—(a) rheumatoid arthritis: mononeuritis, cervical cord compression; (b) Sjögren’s syndrome: sensory neuropathy, myositis, various central nervous system complications; (c) Reiter’s disease: polyneuritis, radiculitis, various central nervous system manifestations....
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- 1 On being a patient
- 2 Modern medicine: foundations, achievements, and limitations
- 3 Global patterns of disease and medical practice
- 4 Cell biology
- 5 Immunological mechanisms
- 6 Principles of clinical oncology
- 7 Infection
- 8 Sexually transmitted diseases and sexual health
- 9 Chemical and physical injuries and environmental factors and disease
- 10 Clinical pharmacology
- 11 Nutrition
- 12 Metabolic disorders
- 13 Endocrine disorders
- 14 Medical disorders in pregnancy
- 15 Gastroenterological disorders
- 16 Cardiovascular disorders
- 17 Critical care medicine
- 18 Respiratory disorders
- 19 Rheumatological disorders
- 20 Disorders of the skeleton
- 21 Disorders of the kidney and urinary tract
- 22 Disorders of the blood
- 23 Disorders of the skin
- 24 Neurological disorders
- 24.1 Introduction and approach to the patient with neurological disease
- 24.2 Mind and brain: building bridges linking neurology, psychiatry, and psychology
- 24.3 Clinical investigation of neurological disease
- 24.4 Higher cerebral function
- 24.5 Epilepsy and disorders of consciousness
- 24.6 Disorders of the special senses
- 24.7 Disorders of movement
- 24.8 Headache
- 24.9 Brainstem syndromes
- 24.10 Specific conditions affecting the central nervous system
- 24.11 Infections of the central nervous system
- 24.12 Disorders of cranial nerves
- 24.13 Disorders of the spinal cord
- 24.14 Diseases of the autonomic nervous system
- 24.15 The motor neuron diseases
- 24.16 Diseases of the peripheral nerves
- 24.17 Inherited neurodegenerative diseases
- 24.18 Developmental abnormalities of the central nervous system
- 24.19 Acquired metabolic disorders and the nervous system
- 24.20 Neurological complications of systemic disease
- 24.21 Paraneoplastic neurological syndromes
- 24.22 Autoimmune limbic encephalitis and Morvan’s syndrome
- 24.23 Disorders of the neuromuscular junction
- 24.24 Disorders of muscle
- 25 The eye
- 26 Psychiatry and drug related problems
- 27 Forensic medicine
- 28 Sports medicine
- 29 Geratology
- 30 Pain
- 31 Palliative medicine
- 32 Biochemistry in medicine
- 33 Acute medicine