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Management of skin disease 

Management of skin disease
Management of skin disease

Rod Sinclair


July 30, 2015: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.


Discussion of use of ingenol mebutate (Australian milkthistle) for actinic keratosis.

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date: 15 October 2021

Topical therapy employs a vehicle (ointments, creams, lotions, gels) to deliver an active ingredient to the skin, to provide a protective barrier, or to hydrate and moisturize the skin. There are many types of topical treatments, including (1) antipruritics, e.g. calamine, are used to relieve itching; (2) keratolytics, e.g. salicylic acid, urea, are used to remove hyperkeratotic skin; (3) tars act by reducing the thickness of the epidermis; (4) corticosteroids have anti-inflammatory and immunosuppressive effects that are useful in treating many skin disorders; (5) calcipotriol (an analogue of 1,25-dihydroxycholecalciferol) reduces epidermal proliferation and is used in local treatment of plaque psoriasis; (6) retinoids influence immune function and have some anti-inflammatory activity and are used in acne; (7) antiseptics, e.g. benzoyl peroxide, chlorhexidine; (8) antifungal agents; (9) sunscreens; (10) anaesthetics/analgesics....

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