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Disorders of pigmentation 

Disorders of pigmentation
Disorders of pigmentation

Eugene Healy


July 30, 2015: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.


Several minor updates made, including on (1) vitiligo as a protective factor for skin cancer; (2) Hermansky-Pudlak syndrome.

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date: 27 September 2021

Normal human skin colour results from the reflection of light from haemoglobin in blood, and carotenoids and melanin pigmentation in skin. The melanin pigmentation is the major component determining differences in skin colour between races.

Increases and decreases in skin pigmentation (hyperpigmentation and hypopigmentation, respectively) may be localized or generalized, can result from a wide variety of physiological or pathological processes, including both genetic and acquired factors, and may reflect underlying systemic disease....

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