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Acquired coagulation disorders 

Acquired coagulation disorders
Acquired coagulation disorders

T.E. Warkentin



Updated information on frozen plasma, the urgent reversal of coumarin anticoagulation, the withdrawal of Drotrecogin alfa, new oral anticoagulant overanticoagulation, and the treatment of heparin-induced thrombocytopenia (HIT).

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date: 28 September 2021

Acquired disorders of coagulation may be the consequence of many underlying conditions, and although they may share abnormality of a coagulation test, e.g. a prolonged prothrombin time, their clinical effects are diverse and often opposing.

Diagnosis—most acquired disorders of coagulation can be identified by screening haemostasis tests, including (1) prothrombin time (PT); (2) activated partial prothromboplastin time (aPTT); (3) thrombin clotting time (TCT); (4) fibrinogen degradation products (FDPs); (5) the cross-linked fibrin assay (D-dimer); (6) protamine sulphate paracoagulation assay; (7) bleeding time—now rarely required or performed; and (8) complete blood count with examination of a blood film. Few bleeding disorders give normal results in all these tests, but disorders predisposed to thrombosis as a result of deficiency of natural anticoagulants (e.g. antithrombin III, protein C, protein S) must be specifically sought....

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