- 1 On being a patient
- 2 Modern medicine: foundations, achievements, and limitations
- 3 Global patterns of disease and medical practice
- 4 Cell biology
- 5 Immunological mechanisms
- 6 Principles of clinical oncology
- 7 Infection
- 8 Sexually transmitted diseases and sexual health
- 9 Chemical and physical injuries and environmental factors and disease
- 10 Clinical pharmacology
- 11 Nutrition
- 12 Metabolic disorders
- 13 Endocrine disorders
- 14 Medical disorders in pregnancy
- 15 Gastroenterological disorders
- 16 Cardiovascular disorders
- 17 Critical care medicine
- 18 Respiratory disorders
- 19 Rheumatological disorders
- 20 Disorders of the skeleton
- 21 Disorders of the kidney and urinary tract
- 22 Disorders of the blood
- 22.1 Introduction
- 22.2 Haemopoietic stem cells
- 22.3 The leukaemias and other bone marrow disorders
- 22.4 The white cells and lymphoproliferative disorders
- 22.5 The red cell
- 22.6 Haemostasis and thrombosis
- 22.6.1 The biology of haemostasis and thrombosis
- 22.6.2 Evaluation of the patient with a bleeding tendency
- 22.6.3 Disorders of platelet number and function
- 22.6.4 Genetic disorders of coagulation
- 22.6.5 Acquired coagulation disorders
- 22.7 The blood in systemic disease
- 22.8 Blood replacement
- 23 Disorders of the skin
- 24 Neurological disorders
- 25 The eye
- 26 Psychiatry and drug related problems
- 27 Forensic medicine
- 28 Sports medicine
- 29 Geratology
- 30 Pain
- 31 Palliative medicine
- 32 Biochemistry in medicine
- 33 Acute medicine
Acquired coagulation disorders
- Chapter:
- Acquired coagulation disorders
- Author(s):
T.E. Warkentin
- DOI:
- 10.1093/med/9780199204854.003.220605_update_001
Update:
Updated information on frozen plasma, the urgent reversal of coumarin anticoagulation, the withdrawal of Drotrecogin alfa, new oral anticoagulant overanticoagulation, and the treatment of heparin-induced thrombocytopenia (HIT).
Acquired disorders of coagulation may be the consequence of many underlying conditions, and although they may share abnormality of a coagulation test, e.g. a prolonged prothrombin time, their clinical effects are diverse and often opposing.
Diagnosis—most acquired disorders of coagulation can be identified by screening haemostasis tests, including (1) prothrombin time (PT); (2) activated partial prothromboplastin time (aPTT); (3) thrombin clotting time (TCT); (4) fibrinogen degradation products (FDPs); (5) the cross-linked fibrin assay (D-dimer); (6) protamine sulphate paracoagulation assay; (7) bleeding time—now rarely required or performed; and (8) complete blood count with examination of a blood film. Few bleeding disorders give normal results in all these tests, but disorders predisposed to thrombosis as a result of deficiency of natural anticoagulants (e.g. antithrombin III, protein C, protein S) must be specifically sought....
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- 1 On being a patient
- 2 Modern medicine: foundations, achievements, and limitations
- 3 Global patterns of disease and medical practice
- 4 Cell biology
- 5 Immunological mechanisms
- 6 Principles of clinical oncology
- 7 Infection
- 8 Sexually transmitted diseases and sexual health
- 9 Chemical and physical injuries and environmental factors and disease
- 10 Clinical pharmacology
- 11 Nutrition
- 12 Metabolic disorders
- 13 Endocrine disorders
- 14 Medical disorders in pregnancy
- 15 Gastroenterological disorders
- 16 Cardiovascular disorders
- 17 Critical care medicine
- 18 Respiratory disorders
- 19 Rheumatological disorders
- 20 Disorders of the skeleton
- 21 Disorders of the kidney and urinary tract
- 22 Disorders of the blood
- 22.1 Introduction
- 22.2 Haemopoietic stem cells
- 22.3 The leukaemias and other bone marrow disorders
- 22.4 The white cells and lymphoproliferative disorders
- 22.5 The red cell
- 22.6 Haemostasis and thrombosis
- 22.6.1 The biology of haemostasis and thrombosis
- 22.6.2 Evaluation of the patient with a bleeding tendency
- 22.6.3 Disorders of platelet number and function
- 22.6.4 Genetic disorders of coagulation
- 22.6.5 Acquired coagulation disorders
- 22.7 The blood in systemic disease
- 22.8 Blood replacement
- 23 Disorders of the skin
- 24 Neurological disorders
- 25 The eye
- 26 Psychiatry and drug related problems
- 27 Forensic medicine
- 28 Sports medicine
- 29 Geratology
- 30 Pain
- 31 Palliative medicine
- 32 Biochemistry in medicine
- 33 Acute medicine