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Genetic disorders of coagulation 

Genetic disorders of coagulation
Genetic disorders of coagulation

Eleanor S. Pollak

and Katherine A. High



Updated information on gene transfer as a method of treating haemophilia.

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date: 27 September 2021

Much of what is understood about specific coagulation proteins has emerged from the careful study of hereditary disorders of blood coagulation.

Haemophilia is a familial X-linked disorder due to deficiency of either factor VIII (haemophilia A) or factor IX (haemophilia B), components of the intrinsic enzymatic complex that activates factor X. The severity of the disease correlates with predicted concentrations of activated factor protein, and those with activity levels below 1% are defined as having severe disease....

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