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Anaemias resulting from defective maturation of red cells 

Anaemias resulting from defective maturation of red cells
Anaemias resulting from defective maturation of red cells

Stephen J. Fuller

and James S. Wiley



Chapter reviewed. Substantial updates made to sections on the aetiology and pathogenesis of sideroblastic anaemias and acquired idiopathic sideroblastic anaemia and to the treatment and prognosis of acquired idiopathic sideroblastic anaemia.

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date: 28 September 2021

Defective maturation of red cells leads to premature destruction of nucleated red cell precursors before they leave the haematopoietic bone marrow, which results in expansion of the marrow, haemolytic jaundice, peripheral signs of increased erythroid turnover on blood films, and (in long-standing disorders) iron overload due to enhanced absorption....

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