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Megaloblastic anaemia and miscellaneous deficiency anaemias 

Megaloblastic anaemia and miscellaneous deficiency anaemias
Megaloblastic anaemia and miscellaneous deficiency anaemias

A.V. Hoffbrand

and Drew Provan



Discussion of new meta-analyses concerning effects of folate deficiency and folate supplementation on cognitive function/dementia, cardiovascular disease and cancer.

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date: 27 September 2021

Megaloblastic anaemias are characterized by red blood cell macrocytosis. They arise because of inhibition of DNA synthesis in the bone marrow, usually due to deficiency of one or other of vitamin B12 (cobalamin) or folate, but sometimes as a consequence of a drug or a congenital or acquired biochemical defect that disturbs their metabolism, or affects DNA synthesis independent of vitamin B...

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