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Iron metabolism and its disorders 

Iron metabolism and its disorders
Iron metabolism and its disorders

T.M. Cox

and John B. Porter



Section on treatment updated.

Further reading updated.

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date: 19 September 2021

Iron is a component of haem proteins and nonhaem enzyme systems required for oxygen transport, mitochondrial respiration, and other key metabolic reactions. The metal exists in two readily interconvertible redox states (divalent ferrous and trivalent ferric iron) that are highly reactive and toxic to tissues. High-affinity iron-binding proteins, which form stable ferric complexes, have evolved to facilitate iron transport and delivery to sites of storage and utilization, including haem biosynthesis....

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