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Erythropoiesis and the normal red cell 

Erythropoiesis and the normal red cell
Erythropoiesis and the normal red cell

Anna Rita Migliaccio

and Thalia Papayannopoulou



Erythropoiesis – role of the hormone erythroferrone in modulating hepcidin production and thereby iron metabolism, with possible role in iron overload in patients with thalassaemia and sickle cell anaemia.

Myeloproliferative disorders – discussion of newly discovered pathogenic mutations and their therapeutic implications.

Diamond-Blackfan anaemia – loss of function mutations in the GATA-1 gene.

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date: 23 October 2021

Erythropoiesis is a highly regulated, multistep process in which stem cells, after a series of amplification divisions, generate multipotential progenitor cells, then oligo- and finally unilineage erythroid progenitors, and then morphologically recognizable erythroid precursors and mature red cells.

Ontogeny of erythropoiesis—this involves a series of well-coordinated events during embryonic and early fetal life: (1) embryo—the fetal yolk sac makes embryonic haemoglobins; (2) fetus—the main site of erythopoiesis is the liver, which initially produces mainly fetal haemoglobin (Hb F, ...

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