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Myeloma and paraproteinaemias 

Myeloma and paraproteinaemias
Myeloma and paraproteinaemias

Robert A. Kyle

and S. Vincent Rajkumar



Management—discussion of use of lenalidomide after autologous stem cell transplantation; detailed presentation of new data regarding treatment options in patients not eligible for stem cell transplantation; update on new novel agents.

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date: 23 October 2021

The paraproteinaemias are a group of neoplastic (or potentially neoplastic) diseases associated with the proliferation of a single clone of immunoglobulin-secreting plasma cells.

This asymptomatic condition of unknown cause is characterized by a serum paraprotein concentration under 30 g/l, less than 10% monoclonal plasma cells in the bone marrow, and no evidence of end-organ damage (CRAB) hypercalcaemia, renal insufficiency, anemia, and bone lesions related to the plasma cell proliferative process....

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