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James O. Armitage



Treatment—updated information on use of biological agents.

Mature B cell lymphomas—new discussion of management of various subtypes of this disease.

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date: 19 September 2021

Lymphomas are malignancies of lymphoid cells. Genetic abnormalities determine the nature of a lymphoma by leading to the overexpression, underexpression, or abnormal expression of specific genes (‘oncogenes’), which are typically those that regulate cell cycle differentiation, rate of proliferation, and apoptosis.

Clinical features—the usual manifestation is with palpable nontender lymphadenopathy. Symptoms from a large mediastinal mass are a common initial presentation. A significant minority of patients present with fevers, night sweats and/or weight loss. Manifestations due to bone marrow or gastrointestinal tract involvement are seen frequently in some subtypes of disease....

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