- 1 On being a patient
- 2 Modern medicine: foundations, achievements, and limitations
- 3 Global patterns of disease and medical practice
- 4 Cell biology
- 5 Immunological mechanisms
- 6 Principles of clinical oncology
- 7 Infection
- 8 Sexually transmitted diseases and sexual health
- 9 Chemical and physical injuries and environmental factors and disease
- 10 Clinical pharmacology
- 11 Nutrition
- 12 Metabolic disorders
- 13 Endocrine disorders
- 14 Medical disorders in pregnancy
- 15 Gastroenterological disorders
- 16 Cardiovascular disorders
- 17 Critical care medicine
- 18 Respiratory disorders
- 19 Rheumatological disorders
- 20 Disorders of the skeleton
- 21 Disorders of the kidney and urinary tract
- 22 Disorders of the blood
- 22.1 Introduction
- 22.2 Haemopoietic stem cells
- 22.3 The leukaemias and other bone marrow disorders
- 22.4 The white cells and lymphoproliferative disorders
- 22.4.1 Leucocytes in health and disease
- 22.4.2 Introduction to the lymphoproliferative disorders
- 22.4.3 Lymphoma
- 22.4.4 The spleen and its disorders
- 22.4.5 Myeloma and paraproteinaemias
- 22.4.6 Eosinophilia
- 22.4.7 Histiocytoses
- 22.5 The red cell
- 22.6 Haemostasis and thrombosis
- 22.7 The blood in systemic disease
- 22.8 Blood replacement
- 23 Disorders of the skin
- 24 Neurological disorders
- 25 The eye
- 26 Psychiatry and drug related problems
- 27 Forensic medicine
- 28 Sports medicine
- 29 Geratology
- 30 Pain
- 31 Palliative medicine
- 32 Biochemistry in medicine
- 33 Acute medicine
Introduction to the lymphoproliferative disorders
- Chapter:
- Introduction to the lymphoproliferative disorders
- Author(s):
Barbara A. Degar
and Nancy Berliner
- DOI:
- 10.1093/med/9780199204854.003.220402_update_001
Update:
February 27, 2014: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.
Lymphoproliferative disorders occur when the normal mechanisms of control of proliferation of lymphocytes break down, resulting in autonomous, uncontrolled proliferation of lymphoid cells and typically leading to lymphocytosis and/or lymphadenopathy, and sometimes to involvement of extranodal sites, e.g. bone marrow.
These include (1) malignant—clonal in nature, resulting from the uncontrolled proliferation of a single transformed cell, e.g. lymphoma; (2) nonmalignant—polyclonal lymphoproliferative disorders may result from conditions including (a) infections—lymphocytosis is commonly caused by viral infections, e.g. Epsitein–Barr virus (EBV); lymphadenopathy is a common feature of a very wide variety of infections, (b) reactive—conditions such as systemic lupous erythematosus (SLE) and sarcoidosis frequently cause lymphadenopathy....
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- 1 On being a patient
- 2 Modern medicine: foundations, achievements, and limitations
- 3 Global patterns of disease and medical practice
- 4 Cell biology
- 5 Immunological mechanisms
- 6 Principles of clinical oncology
- 7 Infection
- 8 Sexually transmitted diseases and sexual health
- 9 Chemical and physical injuries and environmental factors and disease
- 10 Clinical pharmacology
- 11 Nutrition
- 12 Metabolic disorders
- 13 Endocrine disorders
- 14 Medical disorders in pregnancy
- 15 Gastroenterological disorders
- 16 Cardiovascular disorders
- 17 Critical care medicine
- 18 Respiratory disorders
- 19 Rheumatological disorders
- 20 Disorders of the skeleton
- 21 Disorders of the kidney and urinary tract
- 22 Disorders of the blood
- 22.1 Introduction
- 22.2 Haemopoietic stem cells
- 22.3 The leukaemias and other bone marrow disorders
- 22.4 The white cells and lymphoproliferative disorders
- 22.4.1 Leucocytes in health and disease
- 22.4.2 Introduction to the lymphoproliferative disorders
- 22.4.3 Lymphoma
- 22.4.4 The spleen and its disorders
- 22.4.5 Myeloma and paraproteinaemias
- 22.4.6 Eosinophilia
- 22.4.7 Histiocytoses
- 22.5 The red cell
- 22.6 Haemostasis and thrombosis
- 22.7 The blood in systemic disease
- 22.8 Blood replacement
- 23 Disorders of the skin
- 24 Neurological disorders
- 25 The eye
- 26 Psychiatry and drug related problems
- 27 Forensic medicine
- 28 Sports medicine
- 29 Geratology
- 30 Pain
- 31 Palliative medicine
- 32 Biochemistry in medicine
- 33 Acute medicine