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Introduction to the lymphoproliferative disorders 

Introduction to the lymphoproliferative disorders
Introduction to the lymphoproliferative disorders

Barbara A. Degar

and Nancy Berliner



February 27, 2014: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.

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date: 17 May 2022

Lymphoproliferative disorders occur when the normal mechanisms of control of proliferation of lymphocytes break down, resulting in autonomous, uncontrolled proliferation of lymphoid cells and typically leading to lymphocytosis and/or lymphadenopathy, and sometimes to involvement of extranodal sites, e.g. bone marrow.

These include (1) malignant—clonal in nature, resulting from the uncontrolled proliferation of a single transformed cell, e.g. lymphoma; (2) nonmalignant—polyclonal lymphoproliferative disorders may result from conditions including (a) infections—lymphocytosis is commonly caused by viral infections, e.g. Epsitein–Barr virus (EBV); lymphadenopathy is a common feature of a very wide variety of infections, (b) reactive—conditions such as systemic lupous erythematosus (SLE) and sarcoidosis frequently cause lymphadenopathy....

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