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Primary myelofibrosis 

Primary myelofibrosis
Primary myelofibrosis

Jerry L. Spivak


August 28, 2014: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.


Aetiology—description of insertions/deletions of the calreticulin gene.

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date: 19 September 2021

Myelofibrosis is a reactive process common to many malignant and benign disorders. Primary myelofibrosis is a chronic myeloproliferative disorder of unknown aetiology that involves a multipotent haemopoietic progenitor cell and results in abnormalities in red cell, white cell, and platelet production in association with marrow fibrosis and extramedullary haemopoiesis....

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