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The polycythaemias 

The polycythaemias
The polycythaemias

Stefan O. Ciurea

and Ronald Hoffman

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date: 16 October 2021

Polycythaemia or erythrocytosis is characterized by an abnormal increase in the numbers of red blood cells, leading to an elevation in the haemoglobin concentration and haematocrit (>52% in men and >48% in women). The cause may be either (1) primary—due to an intrinsic defect of haemopoietic stem cells; or (2) secondary—due to extrinsic stimulation of progenitor erythroid cells by circulating growth factors; and the condition needs to be distinguished from (3) pseudopolycythaemia—in which haematocrit is raised because the plasma volume is decreased....

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