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Lawrence B. Gardner

and Chi V. Dang

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date: 24 September 2021

Myelodysplasia is a common haematological disorder that may occur at any age, although prevalence increases with age and most patients are over 60 years old. It is associated with a wide variety of acquired clonal abnormalities that may affect all lineages of blood cells and frequently lead to the development of leukaemia. Some particular chromosomal abnormalities are characteristic, and in a few cases functional studies of candidate genes implicated in the chromosomal abnormalities suggest cause–effect relationships, e.g. an activating mutation in the JAK2 kinase....

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