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Chronic myeloid leukaemia 

Chronic myeloid leukaemia
Chronic myeloid leukaemia

Tariq I. Mughal

and John M. Goldman



This chapter has been substantially updated, in particular with regard to to the continued medical success in the treatment of patients with CML and the challenges in the optimal selection of first-line therapy and monitoring, and the current understanding of the cellular and molecular biology of CML.

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date: 27 September 2021

Chronic myeloid leukaemia has a worldwide incidence of 1 to 2 per 100 000 population. Most cases are caused by translocation of the distal end of chromosome 9 on to chromosome 22 (known as a Philadelphia chromosome), which leads to the creation of a fusion protein expressed from the fusion gene formed by juxtaposition of parts of the ...

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