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Chronic lymphocytic leukaemia 

Chronic lymphocytic leukaemia
Chronic lymphocytic leukaemia

Clive S. Zent

and Aaron Polliack



Reviewed June 2013—no significant changes required.

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date: 19 September 2021

Chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL) is the most prevalent lymphoid neoplasm in Europe and North America. The ‘cell of origin’ is a mature B lymphocyte that has a rearranged immunoglobulin gene. CLL cells express modest amounts of surface immunoglobulin, and are characterized by defective apoptosis. The cause of CLL is unknown....

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