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Disorders of tubular electrolyte handling 

Disorders of tubular electrolyte handling
Disorders of tubular electrolyte handling

Nine V.A.M. Knoers

and Elena N. Levtchenko



New information on Autosomal dominant isolated renal hypomagnesemia and EAST/SESAME syndrome

Tables and text have been updated throughout

Updated further reading

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date: 27 September 2021

Physiology—glucose reabsorption in the proximal tubule is carried out by two different pairs of apical Na+-dependent (SGLT1 and 2) and basolateral Na+-independent (GLUT1 and 2) glucose transporters.

Clinical disorders—abnormalities in renal glucose transport can be seen in association with other defects of proximal tubular transport (Fanconi syndrome, see below). Familial renal glycosuria is a rare autosomal recessive condition caused by mutations in the SGLT2-encoding gene, ...

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