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The renal tubular acidoses 

The renal tubular acidoses
The renal tubular acidoses

John A. Sayer

and Fiona E. Karet



Chapter updated throughout

New figure added showing an algorithm approach to a patient with hyperchloraemic metabolic acidosis.

Further reading updated to reflect most recent research

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date: 27 September 2021

Renal tubular acidosis (RTA) arises when the kidneys either fail to excrete sufficient acid, or are unable to conserve bicarbonate, both circumstances leading to metabolic acidosis of varying severity with altered serum potassium. Proximal and distal types of RTA can be differentiated according to which nephron segment is malfunctioning. The condition may be secondary (e.g. associated with drugs, autoimmune disease, or diabetes mellitus) or inherited, and there may be renal tract calcification and—in chronic cases—metabolic bone disease....

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