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Sickle-cell disease and the kidney 

Sickle-cell disease and the kidney
Sickle-cell disease and the kidney

G R Serjeant


May 25, 2011: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.

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date: 19 September 2021

The vasa rectae system of the renal medulla is uniquely conducive to sickling, which leads to vascular damage and tubular dysfunction, including an inability to concentrate the urine. Renal presentations include nocturnal enuresis, haematuria (thought to be due to ischaemic lesions of the papillae, including papillary necrosis), and gradually progressive chronic renal failure, which is an important cause of morbidity and death in patients with homozygous sickle-cell disease over the age of 40 years....

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