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Haemolytic uraemic syndrome 

Haemolytic uraemic syndrome
Haemolytic uraemic syndrome

Paul Warwicker

and Timothy H J Goodship


Update: Pregnancy related HUS—frequently associated with mutations in complement components.

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date: 27 September 2021

The haemolytic uraemic syndrome (HUS) is characterized by the triad of: (1) microangiopathic haemolytic anaemia, (2) thrombocytopenia, and (3) acute renal failure. Endothelial cell activation leads to a change in phenotype from an anticoagulant to a procoagulant state.

Diarrhoeal associated (D+) HUS—this accounts for over 90% of cases and is the commonest cause of acute renal failure in children. The usual pathogen is enterohaemorrhagic ...

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