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Antiglomerular basement membrane disease 

Antiglomerular basement membrane disease
Antiglomerular basement membrane disease

Jeremy Levy

and Charles Pusey



Management—report of a recent large cohort study from China.

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date: 27 September 2021

Antiglomerular basement membrane disease (anti-GBM disease, also known as Goodpasture’s disease) is a rare autoimmune disease caused by pathogenic autoantibodies directed against the noncollagenous, C-terminal domain of the α‎-3 chain of type IV collagen (α‎3(IV)NC1). Immunohistology is characteristic, with linear deposition of IgG (sometimes with IgA or IgM) and complement C3 along the GBMs....

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