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Mesangiocapillary glomerulonephritis 

Mesangiocapillary glomerulonephritis
Chapter:
Mesangiocapillary glomerulonephritis
Author(s):

Peter W. Mathieson

DOI:
10.1093/med/9780199204854.003.210806_update_001

Update:

Novel therapies aimed at complement inhibition, e.g. eculizumab, offer exciting potential in this group of diseases, but clinical experience is very limited.

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date: 10 August 2020

Mesangiocapillary glomerulonephritis (MCGN)—which is synonymous with membranoproliferative glomerulonephritis—is diagnosed when renal biopsy reveals glomeruli with a characteristic lobular appearance. Immunohistology and electron microscopy allow further subdivision into three patterns, types I, II (also called dense deposit disease), and III. Clinical presentation is with proteinuria (sometimes nephrotic syndrome) and/or haematuria; hypertension and/or impairment of excretory kidney function may be associated....

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