- 1 On being a patient
- 2 Modern medicine: foundations, achievements, and limitations
- 3 Global patterns of disease and medical practice
- 4 Cell biology
- 5 Immunological mechanisms
- 6 Principles of clinical oncology
- 7 Infection
- 8 Sexually transmitted diseases and sexual health
- 9 Chemical and physical injuries and environmental factors and disease
- 10 Clinical pharmacology
- 11 Nutrition
- 12 Metabolic disorders
- 13 Endocrine disorders
- 14 Medical disorders in pregnancy
- 15 Gastroenterological disorders
- 16 Cardiovascular disorders
- 17 Critical care medicine
- 18 Respiratory disorders
- 19 Rheumatological disorders
- 20 Disorders of the skeleton
- 21 Disorders of the kidney and urinary tract
- 21.1 Structure and function of the kidney
- 21.2 Electrolyte disorders
- 21.3 Clinical presentation of renal disease
- 21.4 Clinical investigation of renal disease
- 21.5 Acute kidney injury
- 21.6 Chronic kidney disease
- 21.7 Renal replacement therapy
- 21.8 Glomerular diseases
- 21.8.1 Immunoglobulin A nephropathy and Henoch–Schönlein purpura
- 21.8.2 Thin membrane nephropathy
- 21.8.3 Minimal-change nephropathy and focal segmental glomerulosclerosis
- 21.8.4 Membranous nephropathy
- 21.8.5 Proliferative glomerulonephritis
- 21.8.6 Mesangiocapillary glomerulonephritis
- 21.8.7 Antiglomerular basement membrane disease
- 21.9 Tubulointerstitial diseases
- 21.10 The kidney in systemic disease
- 21.11 Renal diseases in the tropics
- 21.12 Renal involvement in genetic disease
- 21.13 Urinary tract infection
- 21.14 Disorders of renal calcium handling, urinary stones, and nephrocalcinosis
- 21.15 The renal tubular acidoses
- 21.16 Disorders of tubular electrolyte handling
- 21.17 Urinary tract obstruction
- 21.18 Malignant diseases of the urinary tract
- 21.19 Drugs and the kidney
- 22 Disorders of the blood
- 23 Disorders of the skin
- 24 Neurological disorders
- 25 The eye
- 26 Psychiatry and drug related problems
- 27 Forensic medicine
- 28 Sports medicine
- 29 Geratology
- 30 Pain
- 31 Palliative medicine
- 32 Biochemistry in medicine
- 33 Acute medicine
Mesangiocapillary glomerulonephritis
- Chapter:
- Mesangiocapillary glomerulonephritis
- Author(s):
Peter W. Mathieson
- DOI:
- 10.1093/med/9780199204854.003.210806_update_001
Update:
Novel therapies aimed at complement inhibition, e.g. eculizumab, offer exciting potential in this group of diseases, but clinical experience is very limited.
Mesangiocapillary glomerulonephritis (MCGN)—which is synonymous with membranoproliferative glomerulonephritis—is diagnosed when renal biopsy reveals glomeruli with a characteristic lobular appearance. Immunohistology and electron microscopy allow further subdivision into three patterns, types I, II (also called dense deposit disease), and III. Clinical presentation is with proteinuria (sometimes nephrotic syndrome) and/or haematuria; hypertension and/or impairment of excretory kidney function may be associated....
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- 1 On being a patient
- 2 Modern medicine: foundations, achievements, and limitations
- 3 Global patterns of disease and medical practice
- 4 Cell biology
- 5 Immunological mechanisms
- 6 Principles of clinical oncology
- 7 Infection
- 8 Sexually transmitted diseases and sexual health
- 9 Chemical and physical injuries and environmental factors and disease
- 10 Clinical pharmacology
- 11 Nutrition
- 12 Metabolic disorders
- 13 Endocrine disorders
- 14 Medical disorders in pregnancy
- 15 Gastroenterological disorders
- 16 Cardiovascular disorders
- 17 Critical care medicine
- 18 Respiratory disorders
- 19 Rheumatological disorders
- 20 Disorders of the skeleton
- 21 Disorders of the kidney and urinary tract
- 21.1 Structure and function of the kidney
- 21.2 Electrolyte disorders
- 21.3 Clinical presentation of renal disease
- 21.4 Clinical investigation of renal disease
- 21.5 Acute kidney injury
- 21.6 Chronic kidney disease
- 21.7 Renal replacement therapy
- 21.8 Glomerular diseases
- 21.8.1 Immunoglobulin A nephropathy and Henoch–Schönlein purpura
- 21.8.2 Thin membrane nephropathy
- 21.8.3 Minimal-change nephropathy and focal segmental glomerulosclerosis
- 21.8.4 Membranous nephropathy
- 21.8.5 Proliferative glomerulonephritis
- 21.8.6 Mesangiocapillary glomerulonephritis
- 21.8.7 Antiglomerular basement membrane disease
- 21.9 Tubulointerstitial diseases
- 21.10 The kidney in systemic disease
- 21.11 Renal diseases in the tropics
- 21.12 Renal involvement in genetic disease
- 21.13 Urinary tract infection
- 21.14 Disorders of renal calcium handling, urinary stones, and nephrocalcinosis
- 21.15 The renal tubular acidoses
- 21.16 Disorders of tubular electrolyte handling
- 21.17 Urinary tract obstruction
- 21.18 Malignant diseases of the urinary tract
- 21.19 Drugs and the kidney
- 22 Disorders of the blood
- 23 Disorders of the skin
- 24 Neurological disorders
- 25 The eye
- 26 Psychiatry and drug related problems
- 27 Forensic medicine
- 28 Sports medicine
- 29 Geratology
- 30 Pain
- 31 Palliative medicine
- 32 Biochemistry in medicine
- 33 Acute medicine