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Ken Farrington

and Roger Greenwood



Timing of initiation of dialysis—the IDEAL (Initiating Dialysis Early And Late) study revealed that planned early initiation was not associated with an improvement in survival or clinical outcomes.

Frequency of dialysis—the randomized Frequent Hemodialysis Network Trial showed the benefits of 6 times weekly versus conventional 3 times weekly sessions.

Management of heparin-induced thrombocytopenia—recommendations for the use of heparinoid or argatroban.

Management of hypertension in dialysis patients—discussion of the general move for guidelines to become less prescriptive, recognizing risks of overtreatment as well as of undertreatment.

Management of hyperlipidaemia in dialysis patients—discussion of the findings of the SHARP trial, which showed that lowering LDL cholesterol with simvastatin plus ezetimibe reduced major atherosclerotic events, but did not have significant effects on cardiovascular or total mortality.

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date: 27 September 2021

Over the past four decades, maintenance haemodialysis has proved to be a highly successful treatment for patients with endstage renal disease. In the developed world, the haemodialysis population continues to increase and is becoming more elderly and dependent. However, despite considerable advances in haemodialysis technology and other significant improvements, such as those in renal anaemia management, the long-term clinical outcomes for patients remain much less good than those of other people with comparable characteristics but without renal failure....

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