Show Summary Details
Page of

Skeletal disorders—general approach and clinical conditions 

Skeletal disorders—general approach and clinical conditions
Skeletal disorders—general approach and clinical conditions

R. Smith

and B.P. Wordsworth



Chapter reviewed—minor updates throughout.

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 28 September 2021

Bone is made up of (1) cells—osteoblasts, osteoclasts, and ostoecytes; and (2) extracellular mineralized matrix—roughly one-third organic (90% type I collagen) and two-thirds inorganic (mainly hydroxyapatite). Bone modelling occurs during growth and remodelling throughout life due to the constant processes of osteoclastic bone resorption and osteoblastic bone formation, which are closely linked and regulated within bone multicellular units. In the adult, the replacement of old bone with new occurs at an annual turnover rate of 25% in cancellous bone, and 2 to 3% in cortical bone....

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.