Contents

Disclaimer

Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always check the product information and clinical procedures with the most up to date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work. Except where otherwise stated, drug dosages and recommendations are for the non-pregnant adult who is not breastfeeding.

Show Summary Details
Page of

Kawasaki’s disease 

Kawasaki’s disease
Chapter:
Kawasaki’s disease
Author(s):

Brian W. McCrindle

DOI:
10.1093/med/9780199204854.003.191108_update_001

November 28, 2012: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.

Update:

Pathogenesis—expanded discussion to include specific evidence regarding genetic susceptibility.

Clinical features—new illustration of all of the typical physical features of the diagnostic criteria.

Risk stratification—inclusion of stress echocardiography, MR angiography, and CT angiography. Classification of coronary artery abnormalities updated to emphasize the use of z-scores and identified cutpoints.

Management—(1)General—encouragement of physical activity within the context of any restrictions. (2) Immunosuppressive—enhanced discussion of evidence regarding the role of corticosteroids, also of both risk prediction and alternative treatments for patients not responding to initial IVIG treatment. (3) Long term—discussion a role for intravascular ultrasound to characterize arterial wall structure, particularly in adults suspected of coronary artery complications related to Kawasaki’s disease.

Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 24 October 2021

Kawasaki’s disease is an acute, self-limited, inflammatory vasculitis of unknown aetiology, with a peak incidence under 5 years of age.

Clinical features—the diagnosis is made in the presence of persistent fever for 5 days or more and at least four of the following five clinical signs: (1) nonpurulent conjunctivitis, (2) oropharyngeal inflammation, (3) cervical lymphadenopathy, (4) polymorphous exanthem, and (5) erythema of the palms and soles with subsequent desquamation. Incomplete presentations occur in approximately 25% of patients. The primary complications are cardiac, with coronary artery dilation and aneurysms evident in approximately 15 to 25% of untreated patients....

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.