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Sjögren’s syndrome 

Sjögren’s syndrome
Sjögren’s syndrome

Patrick J.W. Venables

and Elizabeth Price


May 30, 2013: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.


Pathology—enhanced discussion of prediction of development of B-cell lymphoma.

Treatment—expanded discussion of symptomatic treatments for dry eyes and mouth, and of systemic treatments, including biologics.

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date: 27 September 2021

Sjögren’s syndrome is an autoimmune connective tissue disease characterized by dryness of the eyes and mouth and lymphocytic infiltrates in the salivary, lachrymal, and other exocrine glands. Its cause is not known, but the condition may be primary, where the disease exists on its own, or secondary, where it is associated with other rheumatic diseases, most commonly rheumatoid arthritis. It affects women more than men (ratio 9:1) and is the second commonest autoimmune rheumatic disease (after rheumatoid arthritis), but in many patients remains undiagnosed because symptoms are usually mild....

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