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Crystal-related arthropathies 

Crystal-related arthropathies
Crystal-related arthropathies

Edward Roddy

and Michael Doherty


August 28, 2014: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.

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date: 27 September 2021

Many crystals have been associated with arthropathies or periarticular syndromes: only monosodium urate monohydrate (gout), calcium pyrophosphate dehydrate (pseudogout, chondrocalcinosis), and basic calcium phosphates (mainly hydroxyapatite) are common.

Crystals implicated in joint disease are stable, hard particles that exert biological effects via surface-active (activation of humoral and cell-derived mediators, interaction with cell membranes) and mechanical properties. In general, smaller particle size, marked surface irregularity, and high negative surface charge correlate with inflammatory potential....

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