- 1 On being a patient
- 2 Modern medicine: foundations, achievements, and limitations
- 3 Global patterns of disease and medical practice
- 4 Cell biology
- 5 Immunological mechanisms
- 6 Principles of clinical oncology
- 7 Infection
- 8 Sexually transmitted diseases and sexual health
- 9 Chemical and physical injuries and environmental factors and disease
- 10 Clinical pharmacology
- 11 Nutrition
- 12 Metabolic disorders
- 13 Endocrine disorders
- 14 Medical disorders in pregnancy
- 15 Gastroenterological disorders
- 16 Cardiovascular disorders
- 17 Critical care medicine
- 18 Respiratory disorders
- 18.1 Structure and function
- 18.2 The clinical presentation of respiratory disease
- 18.3 Clinical investigation of respiratory disorders
- 18.4 Respiratory infection
- 18.5 The upper respiratory tract
- 18.6 Allergic rhinitis
- 18.7 Asthma
- 18.8 Chronic obstructive pulmonary disease
- 18.9 Bronchiectasis
- 18.10 Cystic fibrosis
- 18.11 Diffuse parenchymal lung diseases
- 18.12 Sarcoidosis
- 18.13 Pneumoconioses
- 18.14 Miscellaneous conditions
- 18.15 Chronic respiratory failure
- 18.16 Lung transplantation
- 18.17 Pleural diseases
- 18.18 Disorders of the thoracic cage and diaphragm
- 18.19 Malignant diseases
- 19 Rheumatological disorders
- 20 Disorders of the skeleton
- 21 Disorders of the kidney and urinary tract
- 22 Disorders of the blood
- 23 Disorders of the skin
- 24 Neurological disorders
- 25 The eye
- 26 Psychiatry and drug related problems
- 27 Forensic medicine
- 28 Sports medicine
- 29 Geratology
- 30 Pain
- 31 Palliative medicine
- 32 Biochemistry in medicine
- 33 Acute medicine
(p. 3311) Chronic obstructive pulmonary disease
- (p. 3311) Chronic obstructive pulmonary disease
August 28, 2014: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.
This chapter has been extensively revised.
Aetiology—expanded discussion of environmental (indoor air pollution) and genetic factors, and the role of ageing.
Epidemiology—worldwide prevalence described by Burden of Obstructive Lung Disease (BOLD) study; worldwide estimates of deaths and disability; mortality related to severity of airflow limitation.
Clinical features—expanded discussions of systemic features and comorbidities; use of the COPD assessment test (CAT); assessment of risk of exacerbations; differential diagnosis; combined assessments in COPD (BODE index, GOLD classification).
Management—updates on newer pharmacological treatments, including phosphodiesterase 4 inhibitors, and recommendations regarding combined treatments. Enhanced discussion of treatment of comorbidities and of surgical approaches, including resection of bullae and lung volume reduction surgery.
Relevant case histories from Oxford Case Histories in Respiratory Medicine have been added to this chapter.
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