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Takayasu’s arteritis 

Takayasu’s arteritis
Chapter:
Takayasu’s arteritis
Author(s):

Yasushi Kobayashi

DOI:
10.1093/med/9780199204854.003.161404_update_003

Update:

Classification – revised. Management – use of anti-TNF-? therapy and anti-IL-6 receptor therapy in refractory cases.

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date: 29 November 2020

Takayasu’s arteritis is a chronic granulomatous vasculitis of unknown cause characterized by stenosis, occlusion, and aneurysm of large elastic arteries, mainly the aorta and its branches. It mainly affects young women, predominantly in Asian, Middle Eastern, and South American countries.

Clinical presentation—symptoms in the acute stage are nonspecific, such as general fatigue and fever, which can persist for months to years. Symptoms in the chronic stage depend on the anatomical location of the vascular lesions, with typical complaints relating to ischaemia of the brain, eyes, or arms. The commonest finding on physical examination is a weak or absent pulse in one or both brachial, radial, and/or ulnar arteries. Bruits can often be heard over affected arteries. Hypertension and aortic insufficiency are strongly associated with poor prognosis....

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