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Influences acting in utero and in early childhood 

Influences acting in utero and in early childhood
Influences acting in utero and in early childhood

D.J.P. Barker



This chapter has been retired and will not be updated further. The subject matter of this chapter is to be found in chapters 16.13.1 and 16.13.2 of this online update.

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date: 24 September 2021

The search for the environmental causes of ischaemic heart disease is generally guided by a ‘destructive’ model, where the causes to be identified are thought to act in adult life and accelerate destructive processes such as the formation of atheroma, rise in blood pressure, and loss of glucose tolerance. By contrast, a ‘developmental’ model for the disease focuses on causes acting on the baby and argues that in responding to undernutrition and other adverse influences, the baby ensures its continued survival and growth at the cost of premature death from ischaemic heart disease and other chronic disorders....

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