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Biology and pathology of atherosclerosis 

Biology and pathology of atherosclerosis
Biology and pathology of atherosclerosis

Robin P. Choudhury

and Edward A. Fisher



This chapter has been completely revised, and now includes content from retired Chapter 16.13.3.

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date: 27 October 2021

Formation of an atheromatous plaque—this is an inflammatory process that involves the contribution of endothelial cells, monocytes, and smooth muscle cells in conjunction with the deposition of atherogenic lipoproteins in the intimal layer of the vascular wall. The initial stage involves activation of the endothelium at regions of nonlaminar flow in vessels resulting in increased permeability to Apo B-containing lipoproteins (LDL). Inflammatory cells, in particular monocytes, are recruited into the intimal layer of the vessel wall via the action of chemokines and adhesion molecules mobilized by activated endothelium....

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