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Cardiac transplantation and mechanical circulatory support 

Cardiac transplantation and mechanical circulatory support
Cardiac transplantation and mechanical circulatory support

Jayan Parameshwar

and Steven Tsui



Indications and use of ventricular assist devices.

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date: 27 September 2021

Cardiac transplantation is the treatment of choice for selected patients with advanced heart failure: median survival exceeds 10 years and recipients enjoy an excellent quality of life, but availability is severely limited by shortage of donor organs. The need for lifelong immunosuppression is associated with side effects, including an increased incidence of malignancy. Newer immunosuppressive agents offer promise in reducing nephrotoxicity of conventional regimens and in delaying the onset of (currently inevitable) cardiac allograft vasculopathy....

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