- 1 On being a patient
- 2 Modern medicine: foundations, achievements, and limitations
- 3 Global patterns of disease and medical practice
- 4 Cell biology
- 5 Immunological mechanisms
- 6 Principles of clinical oncology
- 7 Infection
- 8 Sexually transmitted diseases and sexual health
- 9 Chemical and physical injuries and environmental factors and disease
- 10 Clinical pharmacology
- 11 Nutrition
- 12 Metabolic disorders
- 13 Endocrine disorders
- 14 Medical disorders in pregnancy
- 15 Gastroenterological disorders
- 15.1 Structure and function of the gut
- 15.2 Symptomatology of gastrointestinal disease
- 15.3 Methods for investigation of gastrointestinal disease
- 15.4 Common acute abdominal presentations
- 15.5 Immune disorders of the gastrointestinal tract
- 15.6 The mouth and salivary glands
- 15.7 Diseases of the oesophagus
- 15.8 Peptic ulcer disease
- 15.9 Hormones and the gastrointestinal tract
- 15.10 Malabsorption
- 15.11 Crohn’s disease
- 15.12 Ulcerative colitis
- 15.13 Irritable bowel syndrome and functional bowel disorders
- 15.14 Colonic diverticular disease
- 15.15 Congenital abnormalities of the gastrointestinal tract
- 15.16 Cancers of the gastrointestinal tract
- 15.17 Vascular and collagen disorders
- 15.18 Gastrointestinal infections
- 15.19 Structure and function of the liver, biliary tract, and pancreas
- 15.20 Jaundice
- 15.21 Hepatitis and autoimmune liver disease
- 15.21.1 Viral hepatitis—clinical aspects
- 15.21.2 Autoimmune hepatitis
- 15.21.3 Primary biliary cirrhosis
- 15.21.4 Primary sclerosing cholangitis
- 15.22 Other disorders of the liver
- 15.23 Diseases of the gallbladder and biliary tree
- 15.24 Diseases of the pancreas
- 15.25 Congenital disorders of the liver, biliary tract, and pancreas
- 15.26 Miscellaneous disorders of the bowel and liver
- 16 Cardiovascular disorders
- 17 Critical care medicine
- 18 Respiratory disorders
- 19 Rheumatological disorders
- 20 Disorders of the skeleton
- 21 Disorders of the kidney and urinary tract
- 22 Disorders of the blood
- 23 Disorders of the skin
- 24 Neurological disorders
- 25 The eye
- 26 Psychiatry and drug related problems
- 27 Forensic medicine
- 28 Sports medicine
- 29 Geratology
- 30 Pain
- 31 Palliative medicine
- 32 Biochemistry in medicine
- 33 Acute medicine
Primary biliary cirrhosis
- Chapter:
- Primary biliary cirrhosis
- Author(s):
M.F. Bassendine
and D.E.J. Jones
- DOI:
- 10.1093/med/9780199204854.003.152103_update_001
Treatment—discussion of response criteria or UDCA therapy, with need for targeting of second line treatments at non-responders.
A relevant case history from Oxford Case Histories in Gastroenterology and Hepatology has been added to this chapter.
Case History—A 60 yr old woman presenting with abnormal liver blood tests.
Primary biliary cirrhosis is a chronic, cholestatic liver disease in which the biliary epithelial cells lining the small intrahepatic bile ducts are the target for immune-mediated damage leading to progressive ductopenia. The cause is unknown, but presumed to be autoimmune....
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- 1 On being a patient
- 2 Modern medicine: foundations, achievements, and limitations
- 3 Global patterns of disease and medical practice
- 4 Cell biology
- 5 Immunological mechanisms
- 6 Principles of clinical oncology
- 7 Infection
- 8 Sexually transmitted diseases and sexual health
- 9 Chemical and physical injuries and environmental factors and disease
- 10 Clinical pharmacology
- 11 Nutrition
- 12 Metabolic disorders
- 13 Endocrine disorders
- 14 Medical disorders in pregnancy
- 15 Gastroenterological disorders
- 15.1 Structure and function of the gut
- 15.2 Symptomatology of gastrointestinal disease
- 15.3 Methods for investigation of gastrointestinal disease
- 15.4 Common acute abdominal presentations
- 15.5 Immune disorders of the gastrointestinal tract
- 15.6 The mouth and salivary glands
- 15.7 Diseases of the oesophagus
- 15.8 Peptic ulcer disease
- 15.9 Hormones and the gastrointestinal tract
- 15.10 Malabsorption
- 15.11 Crohn’s disease
- 15.12 Ulcerative colitis
- 15.13 Irritable bowel syndrome and functional bowel disorders
- 15.14 Colonic diverticular disease
- 15.15 Congenital abnormalities of the gastrointestinal tract
- 15.16 Cancers of the gastrointestinal tract
- 15.17 Vascular and collagen disorders
- 15.18 Gastrointestinal infections
- 15.19 Structure and function of the liver, biliary tract, and pancreas
- 15.20 Jaundice
- 15.21 Hepatitis and autoimmune liver disease
- 15.21.1 Viral hepatitis—clinical aspects
- 15.21.2 Autoimmune hepatitis
- 15.21.3 Primary biliary cirrhosis
- 15.21.4 Primary sclerosing cholangitis
- 15.22 Other disorders of the liver
- 15.23 Diseases of the gallbladder and biliary tree
- 15.24 Diseases of the pancreas
- 15.25 Congenital disorders of the liver, biliary tract, and pancreas
- 15.26 Miscellaneous disorders of the bowel and liver
- 16 Cardiovascular disorders
- 17 Critical care medicine
- 18 Respiratory disorders
- 19 Rheumatological disorders
- 20 Disorders of the skeleton
- 21 Disorders of the kidney and urinary tract
- 22 Disorders of the blood
- 23 Disorders of the skin
- 24 Neurological disorders
- 25 The eye
- 26 Psychiatry and drug related problems
- 27 Forensic medicine
- 28 Sports medicine
- 29 Geratology
- 30 Pain
- 31 Palliative medicine
- 32 Biochemistry in medicine
- 33 Acute medicine