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Primary biliary cirrhosis 

Primary biliary cirrhosis
Primary biliary cirrhosis

M.F. Bassendine

and D.E.J. Jones


Treatment—discussion of response criteria or UDCA therapy, with need for targeting of second line treatments at non-responders.

A relevant case history from Oxford Case Histories in Gastroenterology and Hepatology has been added to this chapter.

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date: 25 October 2021

Case History—A 60 yr old woman presenting with abnormal liver blood tests.

Primary biliary cirrhosis is a chronic, cholestatic liver disease in which the biliary epithelial cells lining the small intrahepatic bile ducts are the target for immune-mediated damage leading to progressive ductopenia. The cause is unknown, but presumed to be autoimmune....

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