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Coeliac disease 

Coeliac disease
Coeliac disease

Patrick C.A. Dubois

and David A. van Heel



Additional information on duodenal bulb biopsies, anti-deamidated gliadin peptide (DGP) antibodies, and pneumococcal vaccination.

A relevant case history has been added.

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date: 20 September 2021

Case History—A 38 yr old woman presenting with a long history of tiredness and abdominal bloating.

Coeliac disease is a common disorder of the small intestine in which storage proteins in dietary wheat, rye, and barley (gliadin, secalins, hordeins, usually referred to as ‘gluten’) induce T-cell responses restricted by HLA DQ2 or DQ8. This immune response drives intestinal inflammation and loss of villous architecture and can lead to a wide spectrum of clinical manifestations....

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