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Immune disorders of the gastrointestinal tract 

Immune disorders of the gastrointestinal tract
Immune disorders of the gastrointestinal tract

D.J. Unsworth



Autoimmunity and the gastrointestinal tract—description of a rare monogenic autoimmune condition, IPEX 1 (immunodysregulation, polyendocrinopathy, enteropathy).

Coeliac disease—expanded discussion of genetic background and pathogenesis.

Skin prick tests—discussion of use of serum-based assays to determine optimal timing.

Antibody tests—comment on allergen component specific IgE antibody tests, which may have enhanced specificity, and a cautionary note regarding other non-IgE tests that must be interpreted with extreme caution.

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date: 20 September 2021

The gastrointestinal tract is protected by gut-associated lymphoid tissue that provides an environment where interaction occurs between luminal antigen and specially adapted immune tissue in Peyer’s patches (small intestine only) or lymphoid follicles. T and B lymphocytes primed in the gut migrate into the systemic circulation via the thoracic duct but home preferentially to the lamina propria of the intestine. Plasma cells of the lamina propria secrete immunoglobulin A as a dimer linked by a joining peptide....

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