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Infections in pregnancy 

Infections in pregnancy
Infections in pregnancy

Lawrence Impey



HIV—expanded discussion of approaches to reduce the risk of mother-to-child transmission.

Streptococci—comments on recent increase in maternal deaths in the United Kingdom due to group A streptococci.

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date: 17 September 2021

Maternal illness is often more severe in pregnancy, e.g. varicella, malaria, and the treatment of infections in pregnancy is complicated by potential effects of drugs on the fetus. Peri- and postpartum maternal infection is a major cause of maternal mortality.

The effects of infection in pregnancy can be broadly categorized as follows (these are not mutually exclusive): (1) transplacental infection causing fetal malformation, e.g. treponema pallidum, rubella; (2) transplacental infection causing severe in utero illness, e.g. parvovirus; (3) neonatal infection / carrier status as a result of transplacental or intrapartum infection, e.g. HIV, herpes zoster; such neonatal infection may be severe; (4) preterm delivery, late miscarriage, perinatal death and cerebral palsy at term delivery are more common in the presence of in utero and placental infection (chorioamnionitis), e.g. Group B streptococcus....

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